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This leaves more serotonin available, which enhances neurotransmission and improves mood.

SSRIs are called selective because they seem to affect serotonin significantly more than other neurotransmitters.

The strategy behind rational drug development is to design a new drug that is capable of affecting a specific neural site of action (e.g., uptake pumps, receptors) while avoiding effects on other site of actions.

The goal in such development is to produce agents that are more efficacious, safer and better tolerated than older medications.

Based on "Essential Psychopharmacology" written by Stephen M.Buspar may have a role in the augmentation of other medications, but has not been proven to be effective for treatment of panic disorder by itself.There are studies which suggest that panic disorder is best treated with a combination of medications and cognitive-behavioral therapy.All SSRIs are non-controlled prescription-only medications. Although all SSRI drugs have the same mechanism of action, each SSRI has slightly different pharmacological and pharmacokinetic characteristics.This leads to differences among the SSRIs in their half-lives, clinical activity, side effects, and drug interactions.

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